Products for Research Use Only
RegisterLogin

Contilisant

CAT: 0804-HY-123928Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-123928Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Contilisant is a permeable antioxidant and neuroprotectant agent. Contilisant exhibits high nM affinity at H3R. Contilisant inhibits monoamine oxidases and cholinesterases. Contilisant has a binding affinity of 65.23 nM towards hS1R. Contilisant can significantly restore cognitive deficit induced by Aβ1-42 in the radial maze assay of Alzheimer’s animal model[1].
CAS Number
2135615-68-6
UNSPSC
12352005
Target
Cholinesterase (ChE) ; Histamine Receptor; Monoamine Oxidase; Reactive Oxygen Species (ROS)
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Neurological Disease
Smiles
C#CCN(C)CC(N1C)=CC2=C1C=CC(OCCCN3CCCCC3)=C2
Molecular Formula
C22H31N3O
Molecular Weight
353.50
References & Citations
[1]Bautista-Aguilera, Ó. M., et al., (2018) . Contilisant, a Tetratarget Small Molecule for Alzheimer's Disease Therapy Combining Cholinesterase, Monoamine Oxidase Inhibition, and H3R Antagonism with S1R Agonism Profile. Journal of medicinal chemistry, 61 (15), 6937-6943.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Popular Products