IVL 745

• Description :

  IVL 745 (XRP 1745A) is a very late antigen 4 (VLA-4, integrin α4β1) antagonist. IVL 745 reduces the airway inflammatory response of sensitized rats and sheep. IVL 745 can be used for airway inflammation and asthma research[1].

• CAS Number :

  [229627-58-1]

• Product Name Alternative :

  XRP 1745A

• UNSPSC :

  12352005

• Target :

  Integrin

• Related Pathways :

  Cytoskeleton

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Smiles :

  O=C(CCN(CC1=CC=C(C(OC)=C1)OC)C(CNC(CC2=CC=C(C(OC)=C2)NC(NC3=CC=CC=C3C)=O)=O)=O)O

• Molecular Formula :

  C31H36N4O8

• Molecular Weight :

  592.64

• References & Citations :

  [1]Norris V, et al. Effect of IVL745, a VLA-4 antagonist, on allergen-induced bronchoconstriction in patients with asthma. J Allergy Clin Immunol. 2005 Oct;116 (4) :761-7.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  α4β1