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K22

CAT: 0804-HY-122668-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-122668-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
K22 is an inhibitor of coronavirus RNA synthesis that specifically targets membrane-associated coronavirus RNA synthesis. K22 effectively blocks replication of multiple coronaviruses by inhibiting the critical step of viral replication complex anchoring to host cell membranes to form double-membrane vesicles (DMVs) . K22 exhibits broad-spectrum antiviral activity against diverse coronaviruses, including Middle East Respiratory Syndrome Coronavirus (MERS-CoV), Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV), Feline Coronavirus (FCoV), Mouse Hepatitis Virus (MHV), and Avian Infectious Bronchitis Virus (IBV) [1].
CAS Number
2141978-86-9
UNSPSC
12352005
Target
SARS-CoV
Related Pathways
Anti-infection
Field of Research
Infection
Purity
98.46
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(N/C(C(N1CCC(O)(C2=CC=C(Br)C=C2)CC1)=O)=C\C3=CC=CC=C3)C4=CC=CC=C4
Molecular Formula
C27H25BrN2O3
Molecular Weight
505.40
References & Citations
[1]Lundin A, et al. Targeting membrane-bound viral RNA synthesis reveals potent inhibition of diverse coronaviruses including the middle East respiratory syndrome virus. PLoS Pathog. 2014 May 29;10 (5) :e1004166.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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