RegisterLogin

Acotiamide-d4

CAT: 804-HY-121467S1Size: 1 EachDry Ice: NoHazardous: No
1 EachSelected
PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Acotiamide-d4 (Z-338 (free base) -d4) is deuterium labeled Acotiamide. Acotiamide is an orally active, selective and reversible acetylcholinesterase (AChE) inhibitor, with an IC50 of 1.79 μM. Acotiamide can enhance gastric contractility and accelerate delayed gastric emptying. Acotiamide has the potential for the research of functional dyspepsia involving gastric motility dysfunction and intestinal inflammatory[1][2][3].
Product Name Alternative
Z-338 (free base) -d4; YM443 (free base) -d4
UNSPSC
12352005
Target
Cholinesterase (ChE) ; Isotope-Labeled Compounds
Related Pathways
Neuronal Signaling; Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology
Smiles
O=C(NC([2H])(C([2H])(N(C(C)C)C(C)C)[2H])[2H])C1=CSC(NC(C2=CC(OC)=C(C=C2O)OC)=O)=N1
Molecular Formula
C21H26D4N4O5S
Molecular Weight
454.58
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Kazuyoshi Y oshii, et al. Physiologically-Based Pharmacokinetic and Pharmacodynamic Modeling for the Inhibition of Acetylcholinesterase by Acotiamide, A Novel Gastroprokinetic Agent for the Treatment of Functional Dyspepsia, in Rat Stomach. Pharmaceutical Research, 33 (2), 292–300.|[3]Hiroshi Yamawaki, et al. Acotiamide attenuates central urocortin 2-induced intestinal inflammatory responses, and urocortin 2 treatment reduces TNF-α productions in LPS-stimulated macrophage cell lines. Neurogastroenterol Motil. 2020 Aug;32 (8) :e13813.|[4]Matsunaga Y, Acotiamide hydrochloride (Z-338), a new selective acetylcholinesterase inhibitor, enhances gastric motility without prolonging QT interval in dogs: comparison with cisapride, itopride, and mosapride. J Pharmacol Exp Ther. 2011 Mar;336 (3) :791-800.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

Related Products

CatalogName
HY-121467-01Acotiamide
HY-121467A-01Acotiamide (hydrochloride)
HY-121467SAcotiamide-d6
HY-121467AS-01Acotiamide-d6 (hydrochloride)
HY-B2155-01Acotiamide (monohydrochloride trihydrate)
HY-B2155R-01Acotiamide (monohydrochloride trihydrate) (Standard)
HY-151912S-01Picolinafen-d4 (4-Fluorophenyl-d4)
HY-132468SKeto Pioglitazone-d4 (M-III-d4)
HY-W654154Dexmedetomidine-d4 L-tartrate (-d4-major)
HY-151892SGlimepiride-d4 (phenylethyl-α, α, β, β-d4) (cis/trans)

Alternative Products

CatalogName
T22230-01Acotiamide
OR1032053Acotiamide
MBS5802355Acotiamide
C10688Acotiamide
T63237-01Acotiamide hydrochloride
MBS576298Acotiamide HCl
OR1068168-01Acotiamide hydrochloride
OR1007622-01Acotiamide Impurity
C10479-01Acotiamide hydrochloride
440916-01Acotiamide Hydrochloride

Popular Products