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Fluorofenidone (Standard)

CAT: 0804-HY-121246R-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-121246R-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Fluorofenidone (Standard) is the analytical standard of Fluorofenidone (AKF-PD). This product is intended for research and analytical applications. Fluorofenidone is an orally active compound with anti-fibrotic, antioxidant, and anti-inflammatory pharmacological effects. Fluorofenidone downregulates the expression of ACSL4, upregulates GPX4 expression and inhibits the NF-κB signaling pathway to alleviate inflammation and fibrosis. Fluorofenidone ameliorates cholestasis and fibrosis by inhibiting hepatic Erk/-Egr-1 signaling and Tgfβ1/Smad pathway in mice. Fluorofenidone demonstrates protective effects against chronic lung injury in mice. Fluorofenidone can be used for the study of chronic obstructive pulmonary disease (COPD), pulmonary interstitial fibrosis (PIF) and non-small cell lung cancer (NSCLC)[2][3].
CAS Number
848353-85-5
UNSPSC
12352100
Target
ERK; NF-κB; Reference Standards; TGF-beta/Smad
Related Pathways
MAPK/ERK Pathway; NF-κB; Others; Stem Cell/Wnt; TGF-beta/Smad
Field of Research
Inflammation/Immunology
Smiles
O=C1C=CC(C)=CN1C2=CC=CC(F)=C2
Molecular Formula
C12H10FNO
Molecular Weight
203.21
References & Citations
[1]Wu Y, et al. Fluorofenidone alleviates cigarette smoke exposure-induced chronic lung injury by targeting ferroptosis. Sci Rep. 2024 Dec 30;14 (1) :32149.|[2]Wang H, et al. Fluorofenidone ameliorates cholestasis and fibrosis by inhibiting hepatic Erk/-Egr-1 signaling and Tgfβ1/Smad pathway in mice. Biochim Biophys Acta Mol Basis Dis. 2022 Dec 1;1868 (12) :166556.|[3]Wang S, et al. Fluorofenidone enhances cisplatin efficacy in non-small cell lung cancer: a novel approach to inhibiting cancer progression. Transl Lung Cancer Res. 2024 Nov 30;13 (11) :3175-3188.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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