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GEBR-7b

CAT: 0804-HY-121041Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-121041Size:1 Each
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Description
GEBR-7b is a selective PDE4D inhibitor with an IC50 of 0.67 μM. GEBR-7b increases hippocampal cAMP and does not influence Aβ levels in rodents. GEBR-7b also improves spatial and can be used for the study of cognitive deficits[1][2].
CAS Number
1776944-03-6
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Neurological Disease
Smiles
COC1=CC=C(C=C1OC2CCCC2)/C=N/OCC(N3CC(C)OC(C)C3)=O
Molecular Formula
C21H30N2O5
Molecular Weight
390.47
References & Citations
[1]Bruno O, et al. New selective phosphodiesterase 4D inhibitors differently acting on long, short, and supershort isoforms. J Med Chem. 2009 Nov 12;52 (21) :6546-57.|[2]Bruno O, et al. GEBR-7b, a novel PDE4D selective inhibitor that improves memory in rodents at non-emetic doses. Br J Pharmacol. 2011 Dec;164 (8) :2054-63.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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