GEBR-7b

• Description:

  GEBR-7b is a selective PDE4D inhibitor with an IC50 of 0.67 μM. GEBR-7b increases hippocampal cAMP and does not influence Aβ levels in rodents. GEBR-7b also improves spatial and can be used for the study of cognitive deficits[1][2].

• UNSPSC:

  12352005

• Target:

  Phosphodiesterase (PDE)

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Neurological Disease

• Smiles:

  COC1=CC=C(C=C1OC2CCCC2)/C=N/OCC(N3CC(C)OC(C)C3)=O

• Molecular Formula:

  C21H30N2O5

• Molecular Weight:

  390.47

• References & Citations:

  [1]Bruno O, et al. New selective phosphodiesterase 4D inhibitors differently acting on long, short, and supershort isoforms. J Med Chem. 2009 Nov 12;52 (21) :6546-57.|[2]Bruno O, et al. GEBR-7b, a novel PDE4D selective inhibitor that improves memory in rodents at non-emetic doses. Br J Pharmacol. 2011 Dec;164 (8) :2054-63.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1776944-03-6]