CCT077791

CAT: 0804-HY-121009Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-121009Size:1 Each

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Description

CCT077791 is a PCAF (IC50: 7.3 μM (FlashPlate) ; 2.2 μM (Filter assay) ) and p300 histone acetyltransferase inhibitor. CCT077791 reduces total acetylation of histones H3 and H4, levels of specific acetylated lysine marks, and acetylation of α-tubulin. CCT077791 can be used in the research of colorectal cancer[1].

CAS Number

748777-47-1

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Histone Acetyltransferase; Microtubule/Tubulin

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton; Epigenetics

Field of Research

Cancer

Smiles

O=C1C=C(SN1C2=CC=C([N+]([O-])=O)C=C2)Cl

Molecular Formula

C9H5ClN2O3S

Molecular Weight

256.67

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362-P403+P233-P405-P501

References & Citations

[1]Stimson L, et al. Isothiazolones as inhibitors of PCAF and p300 histone acetyltransferase activity. Mol Cancer Ther. 2005 Oct;4 (10) :1521-32.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

CBP/p300; GCN5/PCAF

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