WYE-151650

• Description:

  WYE-151650 is a selective JAK-3 inhibitor. WYE-151650 suppresses IL-2-induced STAT-5 phosphorylation and cell proliferation mediated by JAK-3. WYE-151650 is promising for research of autoimmune diseases[1].

• UNSPSC:

  12352005

• Target:

  JAK; STAT

• Related Pathways:

  Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

• Field of Research:

  Inflammation/Immunology

• Smiles:

  N#CC1=CC=C2N=CN(C3=NC=C4N(C)C(N([C@@H]5CC[C@@H](O)C6=C5C=CC=C6)C4=N3)=O)C2=C1

• Molecular Formula:

  C24H19N7O2

• Molecular Weight:

  437.45

• References & Citations:

  [1]Lin TH, et al. Selective functional inhibition of JAK-3 is sufficient for efficacy in collagen-induced arthritis in mice. Arthritis Rheum. 2010 Aug;62 (8) :2283-93.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  JAK3; STAT5

• CAS Number:

  [1141855-86-8]