Products for Research Use Only
RegisterLogin

STK899704

CAT: 0804-HY-120339Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-120339Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
STK899704 is a tubulin polymerization inhibitor. STK899704 exhibits broad-spectrum inhibitory activity against various cancer cell lines with IC50 values ​​ranging from 0.2 to 1.0 μM. STK899704 disrupts the mitotic spindle structure, inducing G2/M phase cell cycle arrest. STK899704 inhibits the migration ability of HT29 cells by downregulating the FAK-MEK-ERK signaling pathway, thereby suppressing the expression and activity of MMP-2 and MMP-9. STK899704 activates caspase-3/7/8/9, leading to PARP cleavage and inducing apoptosis. STK899704 induces cellular senescence through the p53 pathway. STK899704 can be used in research on skin cancer, lung cancer, colon cancer, and other cancers[1][2][3].
CAS Number
1578247-29-6
UNSPSC
12352005
Target
Apoptosis; Caspase; ERK; FAK; MDM-2/p53; MEK; Microtubule/Tubulin; MMP; PARP
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Epigenetics; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C(OCC)CN1C(C)=C(/C=N/NC(C2=CC3=C4C=CC=CC4=CC=C3O2)=O)C5=C1C=CC=C5
Molecular Formula
C27H23N3O4
Molecular Weight
453.49
References & Citations
[1]Park CW, et al. The Novel Small Molecule STK899704 Promotes Senescence of the Human A549 NSCLC Cells by Inducing DNA Damage Responses and Cell Cycle Arrest. Front Pharmacol. 2018 Apr 16;9:163.|[2]Jang HJ, et al. STK899704 inhibits stemness of cancer stem cells and migration via the FAK-MEK-ERK pathway in HT29 cells. BMB Rep. 2018 Nov;51 (11) :596-601.|[3]Sakchaisri K, et al. Anticancer activity of a novel small molecule tubulin inhibitor STK899704. PLoS One. 2017 Mar 15;12 (3) :e0173311.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 3; Caspase 7; Caspase 8; Caspase 9; ERK; MEK; MMP-2; MMP-9

Alternative Products

CatalogName
MBS5778538STK899704

Popular Products