WAY-126299A

• Description:

  WAY-126299A is an orally active dual-acting 5-1ipoxygenase inhibitor (IC50: 12.2 μM) and leukotriene D4 antagonist (pKB: 6.4) . WAY-126299A inhibits antigen-induced leukotriene-dependent bronchoconstriction. WAY-126299A can be used for research of asthma[1].

• UNSPSC:

  12352005

• Target:

  Leukotriene Receptor; Lipoxygenase

• Related Pathways:

  GPCR/G Protein; Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Smiles:

  O=C([C@H](C1=CC=C2C=C(C=CC2=C1)OCC3=NC4=CC=CC=C4S3)C)N(C)O[Na]

• Molecular Formula:

  C22H19N2NaO3S

• Molecular Weight:

  414.45

• References & Citations:

  [1]Howell RE, et al. Pulmonary pharmacology of WAY-126299A: a dual-acting 5-lipoxygenase inhibitor and leukotriene D4 antagonist. Inflamm Res. 1995 Aug;44 Suppl 2:S170-1.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  5-LOX

• CAS Number:

  [169626-43-1]