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MB725

CAT: 0804-HY-119408Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-119408Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MB725 is an ethylamide analogue of MB710. MB725 increases mRNA levels of a range of p53 target genes, notably PUMA, p21, MDM2, NOXA and BAX. MB725 shows selective anticancer activity against p53-Y220C cancer[1].
CAS Number
2230058-99-6
UNSPSC
12352005
Target
Bcl-2 Family; MDM-2/p53
Related Pathways
Apoptosis
Field of Research
Cancer
Smiles
O=C(NCC)C=1C(O)=C(I)C(=C2SC(=NC21)N(CC)CC)N3C=CC=C3
Molecular Formula
C18H21IN4O2S
Molecular Weight
484.36
References & Citations
[1]Baud MGJ, et al. Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines. Eur J Med Chem. 2018 May 25;152:101-114.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bax

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CatalogName
GTR19194235-01MB725

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