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NSC-60339 (Standard)

CAT: 0804-HY-119172RSize: 1 EachDry Ice: NoHazardous: No
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Description
NSC-60339 (Standard) is the analytical standard of NSC-60339. This product is intended for research and analytical applications. NSC-60339, an efflux pump inhibitor and a substrate of AcrAB-TolC, is a polybasic terephthalic acid derivative studied as a potential cancer chemotherapeutic agent[1][2].
CAS Number
70-09-7
UNSPSC
12352100
Target
Bacterial; Reference Standards
Related Pathways
Anti-infection; Others
Field of Research
Cancer; Infection; Inflammation/Immunology
Smiles
O=C(C1=CC=C(C=C1Cl)C(NC2=CC=C(C=C2)C3=NCCN3)=O)NC4=CC=C(C=C4)C5=NCCN5
Molecular Formula
C26H23ClN6O2
Molecular Weight
486.95
References & Citations
[1]D. W. Yesair, et al. Relationship of Phthalanilide-Lipid Complexes to Uptake and Retention of 2-Chloro-4′,4″-di (2-imidazolin-2-yl) terephthalanilide (NSC 60339) by Sensitive and Resistant P388 Leukemia Cells. CANCER RESEARCH 26 Part 1: 202-207, February 1966.|[2]Yesair DW, et al. The retention or efflux of phthalanilide (NSC 60339) -lipid complexes by sensitive or resistant murine tumor cells and Escherichia coli B. Cancer Res. 1968 Feb;28 (2) :314-9.|[3]Haynes KM, et al. Identification and Structure-Activity Relationships of Novel Compounds that Potentiate the Activities of Antibiotics in Escherichia coli. J Med Chem. 2017 Jul 27;60 (14) :6205-6219.|[4]Abdali N, et al. Reviving Antibiotics: Efflux Pump Inhibitors That Interact with AcrA, a Membrane Fusion Protein of the AcrAB-TolC Multidrug Efflux Pump. ACS Infect Dis. 2017 Jan 13;3 (1) :89-98.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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