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CU239

CAT: 0804-HY-119059Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-119059Size:1 Each
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Description
CU239 is a potent and competitive non-retinoic acid inhibitor of RPE65 with an IC50 for RPE65 isomerase (11-cis retinal) of 6 μM. CCU239 exhibits delayed chromophore regeneration after light bleach, and conferrs a partial protection of the retina against injury from high intensity light. CU239 can be used for the study of retinal degeneration[1].
CAS Number
946249-82-7
UNSPSC
12352005
Target
RPE65
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Metabolic Disease
Smiles
O=C(NC1=CC=C(OC(F)(F)F)C=C1)CC2=CSC(NC(NC3=CC=CC=C3)=O)=N2
Molecular Formula
C19H15F3N4O3S
Molecular Weight
436.41
References & Citations
[1]Shin Y, et al. A novel RPE65 inhibitor CU239 suppresses visual cycle and prevents retinal degeneration. Biochim Biophys Acta Mol Basis Dis. 2018 Jul;1864 (7) :2420-2429.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
T71715-01CU239

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