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E913

CAT: 0804-HY-118962Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-118962Size:1 Each
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Description
E913 is a CCR5 antagonist that competes with the binding of antibodies to CCR5 which recognize the C-terminal half of the second extracellular loop (ECL2B) of CCR5. E913 can specifically block the binding of macrophage inflammatory protein-1alpha (MIP-1alpha) to CCR5 (IC50 = 0.002 μM) and MIP-1alpha-elicited cellular Ca2+ mobilization (IC50 = 0.02 μM) . E913 inhibits the replication of laboratory and primary R5 HIV-1 strains as well as various multidrug-resistant monocyte/macrophage tropic (R5) HIV-1 (IC50 = 0.03-0.06 μM) . E913 can be used for the research of infection, such as HIV-1 infection[1].
CAS Number
342394-93-8
UNSPSC
12352005
Target
CCR; HIV
Related Pathways
Anti-infection; GPCR/G Protein; Immunology/Inflammation
Applications
COVID-19-anti-virus
Field of Research
Infection
Smiles
O=C(N(C12CCN(CC1)CC3=CC=C4OCCOC4=C3)CCCC)C(NC2=O)CC5CCCCC5
Molecular Formula
C28H41N3O4
Molecular Weight
483.64
References & Citations
[1]Maeda K, et al. Novel low molecular weight spirodiketopiperazine derivatives potently inhibit R5 HIV-1 infection through their antagonistic effects on CCR5. J Biol Chem. 2001 Sep 14;276 (37) :35194-200.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
CCR5; HIV-1

Alternative Products

CatalogName
T31593E913

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