RB-90740

CAT: 0804-HY-118722Size: 1 EachDry Ice: NoHazardous: No

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Description

RB-90740 is a type of biological reducing agent. RB-90740 is activated through metabolic reduction and generates cytotoxic products, thereby selectively killing tumor cells (usually in a hypoxic environment) . RB-90740 has selective toxicity towards hypoxic cells, which is mainly achieved by causing DNA strand breaks and activating reducing enzymes (such as Cytochrome P450) . RB-90740 does not initially exhibit cytotoxicity similar to its in vitro properties in hypoxic cells in mouse models. RB-90740 can be used to study the tumor physiological environment[1][2]

CAS Number

108307-65-9

UNSPSC

12352005

Target

Cytochrome P450; DNA/RNA Synthesis

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Field of Research

Cancer

Smiles

CN1CCN(CC1)C2=CC=C3[N+]([O-])=C(C4=NCCN4C3=N2)C5=CC=CC=C5

Molecular Formula

C20H22N6O

Molecular Weight

362.43

References & Citations

[1]Adams GE, Stratford IJ. Bioreductive drugs for cancer therapy: the search for tumor specificity. International Journal of Radiation Oncology* Biology* Physics. 1994 May 15;29 (2) :231-8.|[2]Naylor MA, et al. Fused pyrazine mono-N-oxides as bioreductive drugs III. Characterization of RB 90740 in vitro and in vivo. Anti-Cancer Drugs. 1995 Apr 1;6 (2) :259-69.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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RB-90740

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