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IPS-05002

CAT: 0804-HY-118273Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-118273Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IPS-05002 is an α5β1 antagonist. IPS-05002 can inhibit VEGF-stimulated human umbilical vein endothelial cell (HUVEC) proliferation, adhesion, and migration, and also suppresses tubular network formation. IPS-05002 can upregulate IKB-β, XRCC4, and downregulate Cdc6 in VEGF-induced HUVECs. IPS-05002 can be used for the study of tumor angiogenesis[1].
CAS Number
[1185036-77-4]
UNSPSC
12352005
Target
Integrin
Related Pathways
Cytoskeleton
Field of Research
Cancer; Inflammation/Immunology
Smiles
OC1=C(C2NCCC3=C2NC4=CC=CC=C43)C(N(C(N1)=S)CC5=CC=C(C=C5)F)=O
Molecular Formula
C22H19FN4O2S
Molecular Weight
422.48
References & Citations
[1]Kim, et al. Anti-angiogenic mechanism of IPS-05002, a novel antagonist against integrin a5β1, determined by ProteoChip-based antibody array. BioChip Journal, 10 (3), 174–181.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
α5β1

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