Products for Research Use Only
RegisterLogin

PWZ-029

CAT: 0804-HY-117560Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-117560Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
PWZ-029 is a selective inverse agonist for 5 GABAA receptors. PWZ-029 is a benzodiazepine site ligand. PWZ-029 shows a weak but significant partial agonistic effect at 1- and 3-containing receptors. PWZ-029 significantly increases retention session latency in mouse fibroblast cells. PWZ-029 can improve object recognition in normal and scopolamine-treated rat model[1][2].
CAS Number
164025-33-6
UNSPSC
12352005
Target
GABA Receptor
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
O=C1N(CC2=C(N=CN2C3=CC=C(C=C13)Cl)COC)C
Molecular Formula
C14H14ClN3O2
Molecular Weight
291.73
References & Citations
[1]Milić, M., et al., (2013) . PWZ-029, an inverse agonist selective for α₅ GABAA receptors, improves object recognition, but not water-maze memory in normal and scopolamine-treated rats. Behavioural brain research, 241, 206-213. |[2]Savić, M. M., et al., (2008) . PWZ-029, a compound with moderate inverse agonist functional selectivity at GABA (A) receptors containing alpha5 subunits, improves passive, but not active, avoidance learning in rats. Brain research, 1208, 150-159.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-19229TAK-029
HY-120459Rs-029
HY-120837-01PZ-II-029
HY-128131UCCF-029 (free base)

Alternative Products

CatalogName
M12484-01PWZ-029
T28913-01TAK 029
GTR19190903HDS 029
M13716TBZE-029
C07370-10mM/1mLASTX-029
GTR19196262-01UCCF-029
GTR19198585-01RS 029

Popular Products