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Tetraconazole

CAT: 0804-HY-117089-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-117089-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Tetraconazole is a selective irreversible inhibitor of 14-α-sterol demethylase (CYP51) with antifungal activity. Tetraconazole competitively binds to the enzyme to block fungal ergosterol synthesis, resulting in cell membrane damage. The EC50 of tetraconazole against wheat pathogens is 0.382-0.802 mg/L, and the EC50 against onion root tip meristem cell growth is 6.7 mg/L, and (R) - (+) -Tetraconazole is 1.49-1.98 times more active than (S) - (-) -Tetraconazole. Tetraconazole can also induce oxidative stress and chromosomal aberrations in plant cells[1][2][3].
CAS Number
112281-77-3
UNSPSC
12352005
Hazard Statement
H400
Target
Fungal
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Purity
96.98
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
FC(F)C(F)(F)OCC(C1=CC=C(Cl)C=C1Cl)CN2N=CN=C2
Molecular Formula
C13H11Cl2F4N3O
Molecular Weight
372.15
Precautions
H400
References & Citations
[1]Tong Z, et al. Enantioselective effects of the chiral fungicide tetraconazole in wheat: Fungicidal activity and degradation behavior. Environ Pollut. 2019;247:1-8.|[2]Sieiro-Sampedro T, et al. Tetraconazole alters the methionine and ergosterol biosynthesis pathways in Saccharomyces yeasts promoting changes on volatile derived compounds. Food Res Int. 2020;130:108930.|[3]Macar O. Multiple toxic effects of tetraconazole in Allium cepa L. meristematic cells. Environ Sci Pollut Res Int. 2021 Feb;28 (8) :10092-10099.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported