NY-0173

CAT: 0804-HY-117064Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-117064Size:1 Each
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Description
NY-0173 is an antagonist of Exchange proteins directly activated by cAMP (EPAC), with IC50s of 3.5 μM (EPAC2) and 4.0 μM (EPAC1) respectively. NY-0173 can be used to elucidate the biological functions of EPAC and developing potential novel therapeutics against human diseases[1].
CAS Number
[1801911-86-3]
UNSPSC
12352005
Target
Ras
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Field of Research
Others
Smiles
ClC1=C(Cl)C(Cl)=CC(N/N=C(C#N)/C(C2=NOC(C3CCCCC3)=C2)=O)=C1
Molecular Formula
C18H15Cl3N4O2
Molecular Weight
425.70
References & Citations
[1]Ye N, et al. Structure-Activity Relationship Studies of Substituted 2- (Isoxazol-3-yl) -2-oxo-N'-phenyl-acetohydrazonoyl Cyanide Analogues: Identification of Potent Exchange Proteins Directly Activated by cAMP (EPAC) Antagonists. J Med Chem. 2015 Aug 13;58 (15) :6033-47.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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