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Amorphigenin

CAT: 0804-HY-116640Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-116640Size:1 Each
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Description
Amorphigenin is a trothotenone compound. Amorphigenin inhibits osteoclast differentiation by suppressing the expression of c-Fos and NFATc1 in activated T cells. Amorphigenin degrades melanosome proteins by activating the AMPK-dependent autophagy pathway, but not in dependence of the mTOR pathway. Amorphigenin significantly protects bone mass and reduces bone erosion in a mouse model of inflammatory bone loss. Amorphigenin can be used to study inflammatory bone diseases, postmenopausal osteoporosis, and skin pigmentation disorders[1][2].
CAS Number
4208-09-7
UNSPSC
12352005
Target
AMPK; AP-1; Autophagy; Nuclear Factor of activated T Cells (NFAT)
Related Pathways
Autophagy; Epigenetics; Immunology/Inflammation; PI3K/Akt/mTOR
Field of Research
Endocrinology; Metabolic Disease; Inflammation/Immunology
Smiles
O=C1[C@@]2([C@]([H])(OC3=C1C=CC4=C3C[C@@H](O4)C(CO)=C)COC5=C2C=C(C(OC)=C5)OC)[H]
Molecular Formula
C23H22O7
Molecular Weight
410.42
References & Citations
[1]Lee KW, et al. Root Extract Induces Autophagy-Mediated Melanosome Degradation in mTOR-Independent- and AMPK-Dependent Manner. Curr Issues Mol Biol. 2022 Jun 29;44 (7) :2856-2867.|[2]Kim BG, et al. Amorphigenin inhibits Osteoclast differentiation by suppressing c-Fos and nuclear factor of activated T cells. Anat Cell Biol. 2010 Dec;43 (4) :310-6.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
C-Fos

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CatalogName
T30026-01Amorphigenin

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