Products for Research Use Only
RegisterLogin

(Z) -NMac1

CAT: 0804-HY-115507A-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-115507A-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
(Z) -NMac1 is an Nm23-H1 activator found in Zingiber cassumunar Roxb. (Z) -NMac1 has dual anti-metastatic and anti-proliferative biological activities. (Z) -NMac1 selectively inhibits cancer cell proliferation under glucose starvation conditions by inhibiting mitochondrial complex I activity, leading to ATP depletion and mitochondrial dysfunction. (Z) -NMac1 can be used to study tumors with high oxidative phosphorylation, especially in the glucose-restricted tumor microenvironment[1].
CAS Number
1667730-59-7
UNSPSC
12352005
Target
Mitochondrial Metabolism; Oxidative Phosphorylation
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
COC(C=C1/C=C\C2C(C3=CC(OC)=C(C=C3)OC)C=CCC2)=C(C=C1)OC
Molecular Formula
C24H28O4
Molecular Weight
380.48
References & Citations
[1]Kim B, et al. Nm23-H1 activator phenylbutenoid dimer exerts cytotoxic effects on metastatic breast cancer cells by inducing mitochondrial dysfunction only under glucose starvation. Sci Rep. 2021 Dec 7;11 (1) :23549.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-115507-01NMac1
HY-1659564 (Z), ​7 (Z), ​10 (Z), ​13 (Z), ​16 (Z), ​19 (Z) -​Docosahexaenol
HY-166213Ethyl 6 (Z),9 (Z),12 (Z),15 (Z),18 (Z),21 (Z) -tetracosahexaenoate
HY-1657487 (Z), ​10 (Z), ​13 (Z), ​16 (Z), ​19 (Z) -​Docosapentaenol
HY-1659624 (Z),7 (Z),10 (Z),13 (Z),16 (Z),19 (Z) -Docosahexaenyl acetate
HY-1657207 (Z), ​10 (Z), ​13 (Z), ​16 (Z) -​Docosatetraenol
HY-1243034 (Z),7 (Z),10 (Z),13 (Z),16 (Z) -Nonadecapentaenoic acid
HY-166301Ethyl 4 (Z),7 (Z),10 (Z),13 (Z),16 (Z) -nonadecapentaenoate
HY-1660775 (Z), ​8 (Z), ​11 (Z), ​14 (Z), ​17 (Z) -​Eicosapentaen​ol
HY-165758-017 (Z),10 (Z),13 (Z),16 (Z),19 (Z) -Docosapentaenoyl chloride

Alternative Products

CatalogName
GTR19208437-01NMac1
T70957L-01(E) -NMac1

Popular Products