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L-163958

CAT: 0804-HY-114284Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-114284Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
L-163958 is an efficient, orally active, balanced angiotensin II receptor (AII receptor) antagonist. L-163958 has balanced high affinity for AT1 and AT2, with its IC50 values being 0.16, 0.12, 0.50, and 0.64 nM in rabbit aorta (AT1), rat midbrain (AT2), human adrenal gland (AT1), and human adrenal gland (AT2), respectively. L-163958 has a strong inhibitory effect on the pressor activity in rats. L-163958 can be used for the study of hypertension and related cardiovascular diseases[1].
CAS Number
168473-51-6
UNSPSC
12352005
Target
Angiotensin Receptor
Related Pathways
GPCR/G Protein
Field of Research
Cardiovascular Disease
Smiles
O=C(OC(C)(C)C)NS(=O)(C1=CC=CC=C1C2=CC=C(CN3C(CC)=NN(C4=CC(NC(CCCC)=O)=CC=C4Br)C3=O)C(F)=C2)=O
Molecular Formula
C33H37BrFN5O6S
Molecular Weight
730.64
References & Citations
[1]Chang LL, et al. Potent and orally active angiotensin II receptor antagonists with equal affinity for human AT1 and AT2 subtypes. J Med Chem. 1995 Sep 15;38 (19) :3741-58.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AT1 Receptor; AT2 Receptor

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