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ICSN3250

CAT: 0804-HY-112774Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-112774Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ICSN3250 is a halitulin analogue and specific mTORC1 inhibitor. ICSN3250 directly binds to mTOR's FRB domain and displaces phosphatidic acid (PA), reversing mTORC1 activation. ICSN3250 shows high cytotoxicity in cancer cells (nanomolar concentration) through a caspase-independent cell death mechanism. ICSN3250 specifically inhibits the mTORC1 pathway, inducing autophagy and G0-G1 cell-cycle arrest in cancer cells. ICSN3250 can be used for the study of cancer[1].
CAS Number
1561902-73-5
UNSPSC
12352005
Target
Atg8/LC3; Autophagy; mTOR; p62; Ribosomal S6 Kinase (RSK)
Related Pathways
Autophagy; MAPK/ERK Pathway; PI3K/Akt/mTOR
Field of Research
Cancer
Smiles
OC1=CC(C2=CN(CCCN3CCCCCCCCCCCC3)C=C2C4=CC([N+]([O-])=O)=C(O)C(O)=C4)=CC([N+]([O-])=O)=C1O
Molecular Formula
C31H40N4O8
Molecular Weight
596.67
References & Citations
[1]Nguyen TL, et al. mTOR Inhibition via Displacement of Phosphatidic Acid Induces Enhanced Cytotoxicity Specifically in Cancer Cells. Cancer Res. 2018 Sep 15;78 (18) :5384-5397.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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