Products for Research Use Only
RegisterLogin

NGD 98-2 (hydrochloride)

CAT: 0804-HY-110310Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-110310Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
NGD 98-2 hydrochloride is an orally active corticotropin releasing factor-1 (CRF-1) receptor antagonist
CAS Number
1780390-58-0
UNSPSC
12352005
Target
CRFR
Related Pathways
GPCR/G Protein
Field of Research
Neurological Disease
Smiles
CC1=NC(NC(CC)CC)=C(N=C1C2=CC=C(C=C2OC)OC(F)(F)F)OC.Cl
Molecular Formula
C19H25ClF3N3O3
Molecular Weight
435.87
References & Citations
[1]Hodgetts KJ, Ge P, Yoon T, De Lombaert S, Brodbeck R, Gulianello M, Kieltyka A, Horvath RF, Kehne JH, Krause JE, Maynard GD, Hoffman D, Lee Y, Fung L, Doller D. Discovery of N- (1-ethylpropyl) -[3-methoxy-5- (2-methoxy-4-trifluoromethoxyphenyl) -6-methyl-pyrazin-2-yl]amine 59 (NGD 98-2) : an orally active corticotropin releasing factor-1 (CRF-1) receptor antagonist. J Med Chem. 2011 Jun 23;54 (12) :4187-206. doi: 10.1021/jm200365y. Epub 2011 May 27. PMID: 21618986.|[2]Million M, Zhao JF, Luckey A, Czimmer J, Maynard GD, Kehne J, Hoffman DC, Taché Y. The newly developed CRF1-receptor antagonists, NGD 98-2 and NGD 9002, suppress acute stress-induced stimulation of colonic motor function and visceral hypersensitivity in rats. PLoS One. 2013 Sep 6;8 (9) :e73749. doi: 10.1371/journal.pone.0073749. PMID: 24040053; PMCID: PMC3765344.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

NGD 98-2 hydrochloride
CAS Number1780390-58-0
PubChem CID90488929
IUPAC Name3-methoxy-5-[2-methoxy-4-(trifluoromethoxy)phenyl]-6-methyl-N-pentan-3-ylpyrazin-2-amine;hydrochloride
Molecular FormulaC19H25ClF3N3O3
Molecular Weight435.9
Topological Polar Surface Area65.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count8
Heavy Atom Count29
Formal Charge0
Complexity465
SMILES
CCC(CC)NC1=NC(=C(N=C1OC)C2=C(C=C(C=C2)OC(F)(F)F)OC)C.Cl
InChI
InChI=1S/C19H24F3N3O3.ClH/c1-6-12(7-2)24-17-18(27-5)25-16(11(3)23-17)14-9-8-13(10-15(14)26-4)28-19(20,21)22;/h8-10,12H,6-7H2,1-5H3,(H,23,24);1H
InChIKey
KUZDADGRZQAQGN-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of NGD 98-2 hydrochloride
CAS: 1780390-58-0
CID: 90488929
Formula: C19H25ClF3N3O3
MW: 435.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight435.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count8
Exact Mass435.1536538
Monoisotopic Mass435.1536538
Topological Polar Surface Area65.5 Ų
Heavy Atom Count29
Formal Charge0
Complexity465
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

Related Products

CatalogName
HY-114070NGD 98-2
HY-100318-01NGD-4715
HY-W3362716-Benzylaminopurine, 98% (hydrochloride)
HY-103405ANGD 94-1 (dimaleate)
HY-W104195A3,6-Diaminoacridine hydrochloride, 98%
HY-W012206S1-01DL-Metanephrine (hydrochloride) (a, b, b-d3, 98%)
HY-168107SARS-CoV-2-IN-98
HY-W039939-012-Azido-2-deoxy-D-glucose, 98%
HY-W039917-012-Azido-2-deoxy-D-galactose, 98%
HY-W0733142,2,2-Trifluoroethoxyamine (hydrochloride)

Alternative Products

CatalogName
B5552-10NGD 98-2 hydrochloride
C12160-012-Chloroethylamine hydrochloride 98%
230445-012-Iminothiolane hydrochloride 98+% (HPLC)
230904-012,4-Difluorobenzamidine hydrochloride 98+%
D476802,4-Dinitrophenylhydrazine hydrochloride 98%
GP1243-1gNaltrexone hydrochloride, 98%
GP9056-25mgDoxorubicin hydrochloride, 98%
B10220-01Betaine hydrochloride 98%
P19360-01Pilocarpine hydrochloride 98%
D35400-01Dimethylamine hydrochloride 98%

Popular Products