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CYM5442 (Standard)

CAT: 0804-HY-10968RSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-10968RSize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CYM5442 (Standard) is the analytical standard of CYM5442. This product is intended for research and analytical applications. CYM5442 is a potent, highly-selective and orally active sphingosine 1-phosphate (S1P1) receptor agonist with an EC50 of 1.35 nM. CYM5442 is inactive against S1P2, S1P3, S1P4, and S1P5. CYM5442 activates S1P1-dependent p42/p44-MAPK phosphorylation. CYM5442 exerts retinal neuroprotection. CYM5442 can easily penetrate the central nervous system (CNS) [1][2].
CAS Number
1094042-01-9
UNSPSC
12352100
Target
LPL Receptor; Reference Standards
Related Pathways
GPCR/G Protein; Others
Field of Research
Neurological Disease
Smiles
CCOC1=CC=C(C2=NC(C3=CC=CC4=C3CCC4NCCO)=NO2)C=C1OCC
Molecular Formula
C23H27N3O4
Molecular Weight
409.48
References & Citations
[1]Gonzalez-Cabrera PJ, et al. Full pharmacological efficacy of a novel S1P1 agonist that does not require S1P-like headgroup interactions. Mol Pharmacol. 2008 Nov;74 (5) :1308-18.|[2]Blanco R, et al. The S1P1 receptor-selective agonist CYM-5442 protects retinal ganglion cells in endothelin-1 induced retinal ganglion cell loss. Exp Eye Res. 2017 Nov;164:37-45.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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