Products for Research Use Only
RegisterLogin

Quilseconazole (Standard)

CAT: 0804-HY-109040RSize: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-109040RSize:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Quilseconazole (Standard) is the analytical standard of Quilseconazole. This product is intended for research and analytical applications. Quilseconazole (VT-1129) is an orally active, highly selective fungal cytochrome P450 enzyme Cyp51 inhibitor that can cross the blood-brain barrier. Quilseconazole prevents the synthesis of ergosterol, an important component of the fungal cell membrane, by inhibiting Cyp51. Quilseconazole has minimal effects on human CYP enzymes. Quilseconazole has antifungal activity and can be used in the study of cryptococcal meningitis and other diseases[1].
CAS Number
1340593-70-5
UNSPSC
12352100
Target
Cytochrome P450; Fungal; Reference Standards
Related Pathways
Anti-infection; Metabolic Enzyme/Protease; Others
Field of Research
Infection; Inflammation/Immunology; Neurological Disease
Smiles
O[C@@](CN1C=NN=N1)(C(C=CC(F)=C2)=C2F)C(F)(C3=CC=C(C4=CC=C(OC(F)(F)F)C=C4)C=N3)F
Molecular Formula
C22H14F7N5O2
Molecular Weight
513.37
References & Citations
[1]Lockhart SR, et al. The Investigational Fungal Cyp51 Inhibitor VT-1129 Demonstrates Potent In Vitro Activity against Cryptococcus neoformans and Cryptococcus gattii. Antimicrob Agents Chemother. 2016 Mar 25;60 (4) :2528-31.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

Chemical Information

Quilseconazole

an antifungal agent that inhibits lanosterol 14-alpha-demethylase; structure in first source

CAS Number1340593-70-5
PubChem CID91886002
IUPAC Name(2R)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(tetrazol-1-yl)-1-[5-[4-(trifluoromethoxy)phenyl]-2-pyridinyl]propan-2-ol
Molecular FormulaC22H14F7N5O2
Molecular Weight513.4
XLogP4.3
Topological Polar Surface Area86
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count13
Rotatable Bond Count7
Heavy Atom Count36
Formal Charge0
Complexity727
SMILES
C1=CC(=CC=C1C2=CN=C(C=C2)C([C@](CN3C=NN=N3)(C4=C(C=C(C=C4)F)F)O)(F)F)OC(F)(F)F
InChI
InChI=1S/C22H14F7N5O2/c23-15-4-7-17(18(24)9-15)20(35,11-34-12-31-32-33-34)21(25,26)19-8-3-14(10-30-19)13-1-5-16(6-2-13)36-22(27,28)29/h1-10,12,35H,11H2/t20-/m0/s1
InChIKey
NCEHACHJIXJSPD-FQEVSTJZSA-N
Chemical Structure
2D Structure
2D structure of Quilseconazole
CAS: 1340593-70-5
CID: 91886002
Formula: C22H14F7N5O2
MW: 513.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight513.4
XLogP34.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count13
Rotatable Bond Count7
Exact Mass513.10357184
Monoisotopic Mass513.10357184
Topological Polar Surface Area86 Ų
Heavy Atom Count36
Formal Charge0
Complexity727
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
HY-109040-01Quilseconazole
HY-P2274RArgifin (Standard)
HY-N9362REmodinanthrone (Standard)
HY-N7948RIsomaltotetraose (Standard)
HY-N7640RDeoxylimonin (Standard)
HY-N7617RToralactone (Standard)
HY-N7541RAntrodin A (Standard)
HY-N6739RBeauvericin (Standard)
HY-N6687RCalcimycin (Standard)
HY-N3373RLoganetin (Standard)

Alternative Products

CatalogName
BA1727-5.1Quilseconazole
A19305-50Quilseconazole 50mg
A19305-25Quilseconazole 25mg
A19305-100Quilseconazole 100mg
A19305-10Quilseconazole 10mg
A19305-5Quilseconazole 5mg
A19305-1Quilseconazole 1mg
MBS5802183Quilseconazole Formic acid (1340593-70-5 Free base)
abx098968-01Standard

Popular Products