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GGsTop (Standard)

CAT: 0804-HY-108467RSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-108467RSize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GGsTop (Standard) is the analytical standard of GGsTop. This product is intended for research and analytical applications. GGsTop (Nahlsgen) is a potent, non-toxic, highly selective and irreversible γ-GGT inhibitor, with a Ki of 170 μM for Human GGT. GGsTop shows a pKa of 9.71, also exhibits Kons of 150 and 51 M-1 s-1 against E.coli GGT and human GGT, respectively. GGsTop protects hepatic ischemia-reperfusion injury in rat model[1][2][3].
CAS Number
926281-37-0
UNSPSC
12352100
Target
Reference Standards; γ-Glutamyl Transferase (GGT)
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Cardiovascular Disease
Smiles
O=C(O)CC1=CC=CC(OP(OC)(CCC(N)C(O)=O)=O)=C1
Molecular Formula
C13H18NO7P
Molecular Weight
331.26
References & Citations
[1]Han L, et al. Design, synthesis, and evaluation of gamma-phosphono diester analogues of glutamate as highly potent inhibitors and active site probes of gamma-glutamyl transpeptidase. Biochemistry. 2007 Feb 6;46 (5) :1432-47.|[2]Kamiyama A, et al. Phosphonate-based irreversible inhibitors of human γ-glutamyl transpeptidase (GGT) . GGsTop is a non-toxic and highly selective inhibitor with critical electrostatic interaction with an active-site residue Lys562 for enhanced inhibitory activity. Bioorg Med Chem. 2016 Nov 1;24 (21) :5340-5352.|[3]Tamura K, et al. GGsTop, a novel and specific γ-glutamyl transpeptidase inhibitor, protects hepatic ischemia-reperfusion injury in rats. Am J Physiol Gastrointest Liver Physiol. 2016 Aug 1;311 (2) :G305-12.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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Alternative Products

CatalogName
T15379-01GGsTop
GTR19216051-01GGsTop (Nahlsgen)
460490-01Nahlsgen (GGsTop)
A20160-100GGsTop 100mg
A20160-10GGsTop 10mg
A20160-50GGsTop 50mg
A20160-25GGsTop 25mg
A20160-5GGsTop 5mg
A20160-1GGsTop 1mg
255372GGsTop discontinued. See 460490

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