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AP23848

CAT: 0804-HY-107458Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-107458Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AP23848 is an ATP-dependent kinase inhibitor that effectively and selectively targets the Kit activation loop mutation both in vitro and in vivo, showing anti-tumor activity. AP23848 can inhibit the phosphorylation of the activated Kit mutation and tumor growth in mice, making it suitable for targeting diseases with the D816V mutation, such as systemic mastocytosis (SM) and acute myeloid leukemia (AML) research[1].
CAS Number
834894-21-2
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
C-Kit
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
OC1=CC=CC(CCN2C3=NC(C4CCCC4)=NC(NC5=CC=C(P(CCC)(CCC)=O)C=C5)=C3N=C2)=C1
Molecular Formula
C30H38N5O2P
Molecular Weight
531.63
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Amie S Corbin, et al. In vitro and in vivo activity of ATP-based kinase inhibitors AP23464 and AP23848 against activation-loop mutants of Kit. Blood. 2005 Jul 1;106 (1) :227-34.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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JIB89421-01AP23848

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