AA 344

• Description :

  AA 344 is an orally active antiallergic agent. AA 344 inhibits the IgE, IgGa, Concanavalin A (HY-P2149), Dextran -mediated release of histamine. AA 344 shows inhibitory effects on the homologous passive cutaneous anaphylaxis and the passive systemic anaphylaxis in guinea pigs. AA 344 selectively suppresses the type I allergic reaction[1][2].

• UNSPSC :

  12352005

• Target :

  Histamine Receptor

• Related Pathways :

  GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

• Field of Research :

  Inflammation/Immunology

• Smiles :

  O=C1C(C2=NN=NN2)=COC3=CC=C(CC)C=C13

• Molecular Formula :

  C12H10N4O2

• Molecular Weight :

  242.23

• References & Citations :

  [1]Saijo T, et al. Inhibitory action of 6-ethyl-3- (1H-tetrazol-5-YL) chromone (AA-344) on IgE, IgGa- or chemical agent-induced histamine release from isolated rat mast cells. Jpn J Pharmacol. 1979 Aug;29 (4) :531-40.|[2]Kuriki H, et al. Effect of 6-ethyl-3- (1H-tetrazol-5-yl) chromone (AA-344) on the immediate and delayed hypersensitivity reactions. Jpn J Pharmacol. 1979 Oct;29 (5) :733-44.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [50743-49-2]