AA 344

CAT: 0804-HY-107062Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-107062Size:1 Each
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Description
AA 344 is an orally active antiallergic agent. AA 344 inhibits the IgE, IgGa, Concanavalin A (HY-P2149), Dextran -mediated release of histamine. AA 344 shows inhibitory effects on the homologous passive cutaneous anaphylaxis and the passive systemic anaphylaxis in guinea pigs. AA 344 selectively suppresses the type I allergic reaction[1][2].
CAS Number
[50743-49-2]
UNSPSC
12352005
Target
Histamine Receptor
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Field of Research
Inflammation/Immunology
Smiles
O=C1C(C2=NN=NN2)=COC3=CC=C(CC)C=C13
Molecular Formula
C12H10N4O2
Molecular Weight
242.23
References & Citations
[1]Saijo T, et al. Inhibitory action of 6-ethyl-3- (1H-tetrazol-5-YL) chromone (AA-344) on IgE, IgGa- or chemical agent-induced histamine release from isolated rat mast cells. Jpn J Pharmacol. 1979 Aug;29 (4) :531-40.|[2]Kuriki H, et al. Effect of 6-ethyl-3- (1H-tetrazol-5-yl) chromone (AA-344) on the immediate and delayed hypersensitivity reactions. Jpn J Pharmacol. 1979 Oct;29 (5) :733-44.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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