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Lergotrile

CAT: 0804-HY-107002Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-107002Size:1 Each
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Description
Lergotrile is a potent and orally active dopamine agonist and a prolactin secretion inhibitor. Lergotrile inhibits prolactin release from pituitaries by activating an adenohypophyseal dopamine receptor. Lergotrile has the potential for the research of Parkinson's disease[1][2][3].
CAS Number
36945-03-6
UNSPSC
12352005
Target
Dopamine Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Endocrinology; Neurological Disease
Smiles
ClC1=C2C3=C(N1)C=CC=C3[C@]4([H])[C@@](N(C[C@@H](C4)CC#N)C)([H])C2
Molecular Formula
C17H18ClN3
Molecular Weight
299.80
References & Citations
[1]Clemens JA, et al. Inhibition of prolactin secretion by lergotrile mesylate: mechanism of action. Acta Endocrinol (Copenh) . 1975 Jun;79 (2) :230-7. |[2]Lemberger L, et al. The inhibitory effect of an ergoline derivative (lergotrile, compound 83636) on prolactin secretion in man. J Clin Endocrinol Metab. 1974 Sep;39 (3) :579-84. |[3]Lieberman A, et al. Treatment of Parkinson's disease with lergotrile mesylate. JAMA. 1977 Nov 28;238 (22) :2380-2.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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