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Amustaline

CAT: 0804-HY-106991Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-106991Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Amustaline (S-303) is a compound used for inactivating pathogens in blood components and belongs to the category of nucleic acid-targeted chemical decontaminants. Amustaline has the ability to inactivate viruses and is effective against mosquito-borne viruses such as Chikungunya virus (CHIKV), Dengue virus (DENV), and Zika virus (ZIKV) . When combined with glutathione (Glutathione, GSH), which acts as a neutralizer to counteract adverse reactions, Amustaline ensures the stability of red blood cell membranes. Amustaline is mainly used for inactivating pathogens in red blood cell concentrates (RBCC) to reduce the risk of transfusion-transmitted infections (TTI) [1][2].
CAS Number
878189-87-8
Product Name Alternative
S-303
UNSPSC
12352005
Target
CHIKV; Dengue Virus; Flavivirus
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
O=C(CCNC1=C2C=CC=CC2=NC3=CC=CC=C31)OCCN(CCCl)CCCl
Molecular Formula
C22H25Cl2N3O2
Molecular Weight
434.36
References & Citations
[1]Aubry M, et al. Amustaline (S-303) treatment inactivates high levels of Chikungunya virus in red-blood-cell components.|[2]Aydinok Y, et al. Amustaline-glutathione pathogen-reduced red blood cell concentrates for transfusion-dependent thalassaemia. Br J Haematol. 2019 Aug;186 (4) :625-636.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
GTR19189406-01Amustaline dihydrochloride

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