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Orazipone

CAT: 0804-HY-106981Size: 1 EachDry Ice: NoHazardous: No
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Description
Orazipone (OR 1384) is a small molecule immunomodulator with strong anti-inflammatory properties. Orazipone exerts its immunomodulatory effect by forming reversible thiol complexes, which bind to intracellular signaling proteins and the thiol groups of glutathione. Orazipone exhibits potent anti-eosinophilic activity by inducing apoptosis. Orazipone inhibits activation of inflammatory transcription factors NF-kB and STAT 1 and decreases inducible iNOS expression and NO production in response to inflammatory stimuli. Orazipone reduces NADPH oxidase activity and thereby decreases ROS production. Orazipone has a protective effect in intestinal radiation injury[1][2][3].
CAS Number
137109-78-5
Product Name Alternative
OR 1384
UNSPSC
12352005
Target
Apoptosis; NADPH Oxidase; NF-κB; NO Synthase; Reactive Oxygen Species (ROS) ; STAT
Related Pathways
Apoptosis; Immunology/Inflammation; JAK/STAT Signaling; Metabolic Enzyme/Protease; NF-κB; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
O=C(C)/C(C(C)=O)=C\C1=CC=C(S(=O)(C)=O)C=C1
Molecular Formula
C13H14O4S
Molecular Weight
266.31
References & Citations
[1]Sareila O, et al. Orazipone inhibits activation of inflammatory transcription factors nuclear factor-kappa B and signal transducer and activator of transcription 1 and decreases inducible nitric-oxide synthase expression and nitric oxide production in response to inflammatory stimuli. J Pharmacol Exp Ther. 2008 Feb;324 (2) :858-66.|[2]Boerma M, et al. Orazipone, a locally acting immunomodulator, ameliorates intestinal radiation injury: a preclinical study in a novel rat model. Int J Radiat Oncol Biol Phys. 2006 Oct 1;66 (2) :552-9.|[3]Kankaanranta H, et al. Antieosinophilic activity of orazipone. Mol Pharmacol. 2006 Jun;69 (6) :1861-70.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
INOS; NF-κB; STAT1

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CatalogName
T70843-01Orazipone

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