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Barucainide

CAT: 0804-HY-106718Size: 1 EachDry Ice: NoHazardous: No
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Description
Barucainide is an Ib-class anti-arrhythmic agent (moderately blocking sodium channel) . Barucainide exhibits concentration-dependent inhibitory effects on the maximum upstroke velocity (Vmax) of Purkinje fibers and ventricular muscle in dogs. Barucainide significantly shortens the action potential duration (APD) . Barucainide significantly inhibits the pacemaker activity frequency of atrial tissue in rabbits and the enhanced automaticity of Purkinje fibers under normal resting potential in response to isoproterenol. Barucainide cannot inhibit the abnormal automaticity emission frequency of canine Purkinje fibers induced by barium. Barucainide can be used for research on arrhythmias[1][2].
CAS Number
79784-22-8
UNSPSC
12352005
Target
Sodium Channel
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Cardiovascular Disease
Smiles
CC(C)NCCCCOC1=C(C)N=C(CC2=CC=CC=C2)C3=C1COC3
Molecular Formula
C22H30N2O2
Molecular Weight
354.49
References & Citations
[1]Zehender M, et al. Efficacy and tolerance of the new class IB antiarrhythmic barucainide: an intravenous dose-finding study. Clin Pharmacol Ther. 1991 Jan;49 (1) :78-85. |[2]Takanaka C, Singh BN. Barucainide, a novel class Ib antiarrhythmic agent with a slow kinetic property: electrophysiologic observations in isolated canine and rabbit cardiac muscle. Am Heart J. 1990 May;119 (5) :1050-60.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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