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GYKI 12743

CAT: 0804-HY-106390ASize: 1 EachDry Ice: NoHazardous: No
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Description
GYKI 12743 is a vasoselective, postsynaptic α-adrenoceptor blocker. GYKI 12743 inhibits but does not completely eliminate the cutaneous microcirculatory blood flow reduction evoked by electrical stimulation of the peripheral stump of the cut saphenous nerve in rats. GYKI 12743 can be used for the study of neurological diseases[1].
CAS Number
110714-10-8
UNSPSC
12352005
Target
Adrenergic Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=C(C=CC=N1)N1CCCNCC2OC3=C(C=CC=C3)OC2.Cl
Molecular Formula
C16H20ClN3O3
Molecular Weight
337.80
References & Citations
[1]Pintér E, et al. Noradrenergic and peptidergic sympathetic regulation of cutaneous microcirculation in the rat. Eur J Pharmacol. 1997 Apr 23;325 (1) :57-64.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1

Chemical Information

Gyki 12743
CAS Number110714-10-8
PubChem CID163825
IUPAC Name2-[3-(2,3-dihydro-1,4-benzodioxin-3-ylmethylamino)propyl]pyridazin-3-one;hydrochloride
Molecular FormulaC16H20ClN3O3
Molecular Weight337.80
Topological Polar Surface Area63.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Heavy Atom Count23
Formal Charge0
Complexity438
SMILES
C1C(OC2=CC=CC=C2O1)CNCCCN3C(=O)C=CC=N3.Cl
InChI
InChI=1S/C16H19N3O3.ClH/c20-16-7-3-9-18-19(16)10-4-8-17-11-13-12-21-14-5-1-2-6-15(14)22-13;/h1-3,5-7,9,13,17H,4,8,10-12H2;1H
InChIKey
WJDFSAOMSJHHCG-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Gyki 12743
CAS: 110714-10-8
CID: 163825
Formula: C16H20ClN3O3
MW: 337.80
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight337.80
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Exact Mass337.1193192
Monoisotopic Mass337.1193192
Topological Polar Surface Area63.2 Ų
Heavy Atom Count23
Formal Charge0
Complexity438
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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