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Rotigaptide (Standard)

CAT: 0804-HY-106225RSize: 1 EachDry Ice: NoHazardous: No
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Description
Rotigaptide (Standard) is the analytical standard of Rotigaptide. This product is intended for research and analytical applications. Rotigaptide (ZP123) is a novel and specific modulator of connexin 43 (Cx43) . Rotigaptide prevents the uncoupling of Cx43-mediated gap junction communication and normalizes cell-to-cell communication during acute metabolic stress. Rotigaptide is a potent antiarrhythmic peptide (AAP) with improved stability and has the potential for the investigation of cardiac arrhythmias-specifically?atrial fibrillation[1][2].
CAS Number
355151-12-1
Product Name Alternative
ZP123 (Standard)
UNSPSC
12352005
Target
Connexin; Gap Junction Protein; Reference Standards
Related Pathways
Cytoskeleton; Others
Field of Research
Cardiovascular Disease
Smiles
O=C(N)CNC([C@@H](C)NC(CNC([C@@H]1N(C([C@@H]2N(C([C@@H](CC3=CC=C(O)C=C3)NC(C)=O)=O)CCC2)=O)C[C@@H](O)C1)=O)=O)=O
Molecular Formula
C28H39N7O9
Molecular Weight
617.65
References & Citations
[1]Seyed Mojtaba Ghiasi, et al. The connexin 43 regulator Rotigaptide reduces cytokine-induced cell death in human islets|[2]Stahlhut M, et al. The antiarrhythmic peptide rotigaptide (ZP123) increases connexin 43 protein expression in neonatal rat ventricular cardiomyocytes.Cell Commun Adhes. 2006 Jan-Apr;13 (1-2) :21-7.|[3]Kjølbye AL, et al. Pharmacological modulation of gap junction function with the novel compound rotigaptide: a promising new principle for prevention of arrhythmias.Basic Clin Pharmacol Toxicol. 2007 Oct;101 (4) :215-30.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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