A-620223

CAT: 0804-HY-10615-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-10615-01Size:5 mg

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Description

A-620223 is a PARP-1 inhibitor with a Ki of 8 nM against PARP-1 and EC50 of 3 nM in a whole cell assay. A-620223 demonstrates good in vivo efficacy in a B16F10 subcutaneous murine melanoma model in combination with Temozolomide (TMZ) and in an MX-1 breast xenograph model in combination with Cisplatin (HY-17394). A-620223 can be used for the studies of melanoma and breast cancer[1].

CAS Number

272769-49-0

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

PARP

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Field of Research

Cancer

Purity

98.84

Smiles

CCCN(CC1)CCC1C2=NC3=C(C(N)=O)C=CC=C3N2

Molecular Formula

C16H22N4O

Molecular Weight

286.37

Precautions

H302, H315, H319, H335

References & Citations

[1]Penning TD, et al. Discovery and SAR of 2- (1-propylpiperidin-4-yl) -1H-benzimidazole-4-carboxamide: A potent inhibitor of poly (ADP-ribose) polymerase (PARP) for the treatment of cancer. Bioorg Med Chem. 2008 Jul 15;16 (14) :6965-75.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound2

Clinical Information

No Development Reported

Isoform

PARP1

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