Teloxantrone

CAT: 0804-HY-106090Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-106090Size:1 Each

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Description

Teloxantrone (CI-937; DUP 937) is a DNA synthesis inhibitor (IC50: 0.33 μM) . Teloxantrone has antitumor activity and can be used in colorectal cancer research[1][2].

CAS Number

91441-48-4

Product Name Alternative

CI-937; DUP 937

UNSPSC

12352005

Target

DNA/RNA Synthesis

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Cancer

Smiles

CNCCNC1=C2C3=C(C=C1)N(CCNCCO)N=C3C4=C(C(O)=CC=C4O)C2=O

Molecular Formula

C21H25N5O4

Molecular Weight

411.45

References & Citations

[1]Fry DW, et al. In vitro DNA strand scission and inhibition of nucleic acid synthesis in L1210 leukemia cells by a new class of DNA complexers, the anthra[1,9-cd]pyrazol-6 (2H) -ones (anthrapyrazoles) . Biochem Pharmacol. 1985 Oct 1;34 (19) :3499-508.|[2]Maroun JA, et al. Phase II study on DuP 937 (Teloxantrone) in colorectal carcinoma. A Canadian National Cancer Institute Clinical Trial Group study. Invest New Drugs. 1993 May-Aug;11 (2-3) :235-7.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Phase 1

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