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Sameridine

CAT: 0804-HY-105525Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-105525Size:1 Each
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Description
Sameridine (NIH-10908) is a weak partial agonist of the μ-opioid (μ-opioid) receptor. Sameridine shows local anesthetic and analgesic properties when injected intrathecally. Sameridine has minimal respiratory depression at low doses, but can suppress ventilatory response at high doses. Sameridine can be used for the study of analgesic effect[1][2].
CAS Number
143257-97-0
Product Name Alternative
NIH 10908 (free base)
UNSPSC
12352005
Hazard Statement
H312-H319
Target
Opioid Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=C(C1(CCN(CC1)CCCCCC)C2=CC=CC=C2)N(CC)C
Molecular Formula
C21H34N2O
Molecular Weight
330.51
Precautions
P264-P280-P302+P352-P305+P351+P338-P363-P501
References & Citations
[1]Mulroy MF, et al. Sameridine is safe and effective for spinal anesthesia: a comparative dose-ranging study with lidocaine for inguinal hernia repair. Anesth Analg. 1999 Apr;88 (4) :815-21.|[2]Osterlund A, et al. The effects on resting ventilation of intravenous infusions of morphine or sameridine, a novel molecule with both local anesthetic and opioid properties. Anesth Analg. 1999 Jan;88 (1) :160-5.|[3]Karlsten R, et al. Sameridine--intrathecal injection in the rat. Morphometric and morphologic analysis after chronic administration and effects on spinal cord blood flow. Acta Anaesthesiol Scand. 1999 May;43 (5) :573-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
μ Opioid Receptor/MOR

Alternative Products

CatalogName
GTR19273847-01Sameridine
GTR19234675-01Sameridine hydrochloride

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