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Florifenine

CAT: 0804-HY-105424Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-105424Size:1 Each
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Description
Florifenine is a selective cyclooxygenase (COX) inhibitor with anti-inflammatory activity. Florifenine inhibits TXB2 in human whole blood with an IC50 of 32.5 nM. Florifenine exhibits anti-inflammatory effects in ear oedema. Florifenine inhibits neutrophil migration and reduces PGE2 levles in the inflamed ears. Florifenine inhibits leukocyte migration and PGE2 levels in the air pouch inflammation induced by Zymosan. Florifenine can be used for anti-inflammatory research[1].
CAS Number
83863-79-0
UNSPSC
12352005
Target
COX
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology
Smiles
FC(F)(F)C1=CC=C2C(NC3=C(C=CC=C3)C(OCCN4CCCC4)=O)=CC=NC2=C1
Molecular Formula
C23H22F3N3O2
Molecular Weight
429.43
References & Citations
[1]Bustos G, et al. A study of the novel anti-inflammatory agent florifenine topical anti-inflammatory activity and influence on arachidonic acid metabolism and neutrophil functions. Naunyn Schmiedebergs Arch Pharmacol. 1995 Mar;351 (3) :298-304.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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