L 373890

CAT: 0804-HY-105383Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-105383Size:1 Each

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Description

L 373890 is a selective pyridinone acetamide thrombin inhibitor with a Ki of 0.5 nM. L 373890 shows highly selectivity for thrombin over trypsin (Ki of 570 nM), serine proteases plasmin, tPA, activated protein C, plasma kallikrein and chymotrypsin. L 373890 can be used for thrombosis research[1].

CAS Number

187162-33-0

UNSPSC

12352005

Target

Thrombin

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Smiles

O=S(NC1=CC=C(C)N(CC(NCC2CCN(C(N)=N)CC2)=O)C1=O)(CC3=CC=CC=C3)=O

Molecular Formula

C22H30N6O4S

Molecular Weight

474.58

References & Citations

[1]Philip E.J. Sanderson, et al. L-373,890, An achiral, noncovalent, subnanomolar thrombin inhibitor. Bioorganic & Medicinal Chemistry Letters. Volume 7, Issue 12, 17 June 1997, Pages 1497-1500.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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L 373890

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