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Piromelatine (Standard)

CAT: 0804-HY-105285R-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-105285R-01Size:1 mg
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Description
Piromelatine (Standard) is the analytical standard of Piromelatine. This product is intended for research and analytical applications. Piromelatine (Neu-P11) is a melatonin MT1/MT2 receptor agonist, serotonin 5-HT1A/5-HT1D agonist, and serotonin 5-HT2B antagonist. Piromelatine (Neu-P11) possesses sleep promoting, analgesic, anti-neurodegenerative, anxiolytic and antidepressant potentials. Piromelatine (Neu-P11) also possesses pain-related P2X3, TRPV1, and Nav1.7 channel-inhibition capacities[1][2][3].
CAS Number
946846-83-9
Product Name Alternative
Neu-P11 (Standard)
UNSPSC
12352005
Target
5-HT Receptor; Melatonin Receptor; P2X Receptor; Reference Standards; Sodium Channel; TRP Channel
Related Pathways
GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling; Others
Field of Research
Neurological Disease
Smiles
O=C(C1=CC(C=CO1)=O)NCCC2=CNC3=CC=C(OC)C=C23
Molecular Formula
C17H16N2O4
Molecular Weight
312.32
References & Citations
[1]Meihua She, et al. Piromelatine, a Novel Melatonin Receptor Agonist, Stabilizes Metabolic Profiles and Ameliorates Insulin Resistance in Chronic Sleep Restricted Rats. Eur J Pharmacol. 2014 Mar 15;727:60-5.|[2]L Huang, et al. Blood Pressure Reducing Effects of Piromelatine and Melatonin in Spontaneously Hypertensive Rats. Eur Rev Med Pharmacol Sci. 2013 Sep;17 (18) :2449-56.|[3]Yuan-Yuan Liu, et al. Piromelatine Exerts Antinociceptive Effect via Melatonin, Opioid, and 5HT1A Receptors and Hypnotic Effect via Melatonin Receptors in a Mouse Model of Neuropathic Pain. Psychopharmacology (Berl) . 2014 Oct;231 (20) :3973-85.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Isoform
5-HT1 Receptor;5-HT2 Receptor

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