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Eritoran (tetrasodium)

CAT: 0804-HY-105070ASize: 1 EachDry Ice: NoHazardous: No
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Description
Eritoran tetrasodium (E5564) is a Toll-like receptor 4 (TLR4) antagonist. Eritoran tetrasodium protects mice against lethal influenza virus infection, such as Ebola virus (EBOV), Marburg virus (MARV) . Eritoran tetrasodium decreases the level of granulocytosis, may alleviate the severity of the "cytokine storm". Eritoran tetrasodium inhibits pathogenesis of filovirus infection. Eritoran tetrasodium has anti-inflammatory activity[1][2].
CAS Number
185954-98-7
Product Name Alternative
E5564
UNSPSC
12352005
Target
EBV; Toll-like Receptor (TLR)
Related Pathways
Anti-infection; Immunology/Inflammation
Applications
COVID-19-anti-virus
Field of Research
Infection; Inflammation/Immunology
Solubility
10 mM in DMSO
Smiles
CCCCCCC[C@@H](OC)CCO[C@@H]1[C@H]([C@@H](O[C@H](COC)[C@H]1OP(O[Na])(O[Na])=O)OC[C@@H]2[C@H]([C@@H]([C@@H](NC(CC(CCCCCCCCCCC)=O)=O)[C@@H](OP(O[Na])(O[Na])=O)O2)OCCCCCCCCCC)O)NC(CCCCCCCCC/C=C\CCCCCC)=O
Molecular Formula
C66H122N2Na4O19P2
Molecular Weight
1401.58
References & Citations
[1]Younan P, et al. The Toll-Like Receptor 4 Antagonist Eritoran Protects Mice from Lethal Filovirus Challenge. mBio. 2017 Apr 25;8 (2) :e00226-17|[2]Sun Y, et al. Inhibition of corneal inflammation by the TLR4 antagonist Eritoran tetrasodium (E5564) . Invest Ophthalmol Vis Sci. 2009 Mar;50 (3) :1247-54.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 3

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