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Dapagliflozin-d4

CAT: 0804-HY-10450S2Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-10450S2Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Dapagliflozin-d4 (BMS-512148-d4) is deuterium labeled Dapagliflozin. Dapagliflozin (BMS-512148), a new type of agent used to treat diabetes mellitus (DM), is a competitive sodium/glucose cotransporter 2 (SGLT2) inhibitor, which results in excretion of glucose into the urine[1]. Dapagliflozin induces HIF1 expression and attenuates renal IR injury[2].
CAS Number
1224234-25-6
Product Name Alternative
BMS-512148-d4
UNSPSC
12352005
Target
Isotope-Labeled Compounds; SGLT
Related Pathways
Membrane Transporter/Ion Channel; Others
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Cancer
Smiles
O[C@H]1[C@H](C2=CC(CC3=C([2H])C([2H])=C(C([2H])=C3[2H])OCC)=C(C=C2)Cl)O[C@@H]([C@H]([C@@H]1O)O)CO
Molecular Formula
C21H21D4ClO6
Molecular Weight
412.90
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Pelissier T, et al. The orofacial capsaicin test in rats: effects of different capsaicin concentrations and morphine. Pain. 2002 Mar;96 (1-2) :81-7.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
SGLT2

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