Losmapimod (Standard)

• Description:

  Losmapimod (Standard) is the analytical standard of Losmapimod. This product is intended for research and analytical applications. Losmapimod (GSK-AHAB) is a selective, potent, and orally active p38 MAPK inhibitor with pKis of 8.1 and 7.6 for p38α and p38β, respectively[1].

• Product Name Alternative:

  GSK-AHAB (Standard) ; GW856553X (Standard) ; SB856553 (Standard)

• UNSPSC:

  12352005

• Target:

  Autophagy; p38 MAPK; Reference Standards

• Related Pathways:

  Autophagy; MAPK/ERK Pathway; Others

• Field of Research:

  Inflammation/Immunology; Cancer

• Smiles:

  CC1=C (C2=NC=C (C (NCC (C) (C) C) =O) C=C2) C=C (C (NC3CC3) =O) C=C1F

• Molecular Formula:

  C22H26FN3O2

• Molecular Weight:

  383.46

• References & Citations:

  [1]Willette RN, et al. Differential effects of p38 mitogen-activated protein kinase and cyclooxygenase 2 inhibitors in a model of cardiovascular disease. J Pharmacol Exp Ther. 2009 Sep;330 (3) :964-70.|[2]Zhang XM, et al. Suppression of mitochondrial fission in experimental cerebral ischemia: The potential neuroprotective target of p38 MAPK inhibition. Neurochem Int. 2015 Nov;90:1-8.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• CAS Number:

  585543-15-3