Losmapimod (Standard)

CAT: 0804-HY-10402R-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-10402R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Losmapimod (Standard) is the analytical standard of Losmapimod. This product is intended for research and analytical applications. Losmapimod (GSK-AHAB) is a selective, potent, and orally active p38 MAPK inhibitor with pKis of 8.1 and 7.6 for p38α and p38β, respectively[1].
CAS Number
[585543-15-3]
Product Name Alternative
GSK-AHAB (Standard) ; GW856553X (Standard) ; SB856553 (Standard)
UNSPSC
12352005
Target
Autophagy; p38 MAPK; Reference Standards
Related Pathways
Autophagy; MAPK/ERK Pathway; Others
Field of Research
Inflammation/Immunology; Cancer
Smiles
CC1=C(C2=NC=C(C(NCC(C)(C)C)=O)C=C2)C=C(C(NC3CC3)=O)C=C1F
Molecular Formula
C22H26FN3O2
Molecular Weight
383.46
References & Citations
[1]Willette RN, et al. Differential effects of p38 mitogen-activated protein kinase and cyclooxygenase 2 inhibitors in a model of cardiovascular disease. J Pharmacol Exp Ther. 2009 Sep;330 (3) :964-70.|[2]Zhang XM, et al. Suppression of mitochondrial fission in experimental cerebral ischemia: The potential neuroprotective target of p38 MAPK inhibition. Neurochem Int. 2015 Nov;90:1-8.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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