Canertinib (Standard)

• Description :

  Canertinib (Standard) is the analytical standard of Canertinib. This product is intended for research and analytical applications. Canertinib (CI-1033; PD-183805) is a potent and irreversible EGFR inhibitor; inhibits cellular EGFR and ErbB2 autophosphorylation with IC50s of 7.4 and 9 nM. Canertinib is active against vaccinia virus respiratory infection in mice[1][2][3][4].

• CAS Number :

  [267243-28-7]

• Product Name Alternative :

  CI-1033 (Standard) ; PD-183805 (Standard)

• UNSPSC :

  12352005

• Target :

  EGFR; Orthopoxvirus; Reference Standards

• Related Pathways :

  Anti-infection; JAK/STAT Signaling; Others; Protein Tyrosine Kinase/RTK

• Field of Research :

  Cancer; Infection

• Smiles :

  O=C(NC1=C(C=C2C(C(NC3=CC=C(C(Cl)=C3)F)=NC=N2)=C1)OCCCN4CCOCC4)C=C

• Molecular Formula :

  C24H25ClFN5O3

• Molecular Weight :

  485.94

• References & Citations :

  [1]Smaill JB, et al. Tyrosine kinase inhibitors. 17. Irreversible inhibitors of the epidermal growth factor receptor: 4- (phenylamino) quinazoline- and 4- (phenylamino) pyrido[3,2-d]pyrimidine-6-acrylamides bearing additional solubilizing functions. J Med Chem. 2000 Apr 6;43 (7) :1380-97.|[2]Djerf Severinsson EA, et al. The pan-ErbB receptor tyrosine kinase inhibitor canertinib promotes apoptosis of malignant melanoma in vitro and displays anti-tumor activity in vivo. Biochem Biophys Res Commun. 2011 Oct 28;414 (3) :563-8.|[3]McAndrews KM, et, al. Mechanisms associated with biogenesis of exosomes in cancer. Mol Cancer. 2019 Mar 30;18 (1) :52.|[4]Smee DF, et, al. Progress in the discovery of compounds inhibiting orthopoxviruses in animal models. Antivir Chem Chemother. 2008;19 (3) :115-24.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference Standards