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Nedisertib (Standard)

CAT: 0804-HY-101570RSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-101570RSize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Nedisertib (Standard) is the analytical standard of Nedisertib. This product is intended for research and analytical applications. Nedisertib (Peposertib) is an orally active selective DNA-dependent protein kinase (DNA-PK) inhibitor with an IC50 value of less than 3 nM. Nedisertib also acts as a modulator of ABCG2, capable of reversing ABCG2-mediated multidrug resistance (MDR), thus providing new strategies for combination therapy. By inhibiting DNA double-strand break repair, Nedisertib can enhance the efficacy of chemotherapy and radiotherapy. Nedisertib exhibits antitumor activity[1][2][3].
CAS Number
1637542-33-6
Target
BCRP; DNA-PK; Reference Standards
Related Pathways
Cell Cycle/DNA Damage; Membrane Transporter/Ion Channel; Others; PI3K/Akt/mTOR
Field of Research
Cancer
Smiles
FC1=CC(Cl)=C([C@@H](C2=CC=C(N=N2)OC)O)C=C1C3=NC=NC4=C3C=CC(N5CCOCC5)=C4
Molecular Formula
C24H21ClFN5O3
Molecular Weight
481.91
References & Citations
[1]L. Damstrup, et al. M3814, a DNA-dependent Protein Kinase Inhibitor (DNA-PKi), Potentiates the Effect of Ionizing Radiation (IR) in Xenotransplanted Tumors in Nude Mice. IJROBP. 2016; 94, 940-941.|[2]Thomas Fuchss, et al. Arylchinazoline. WO2014183850A1. 2014-11-20.|[3]Wu ZX, et al. M3814, a DNA-PK Inhibitor, Modulates ABCG2-Mediated Multidrug Resistance in Lung Cancer Cells. Front Oncol. 2020 May 12;10:674.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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