TMI-1 (Standard)

CAT: 0804-HY-101448RSize: 1 EachDry Ice: NoHazardous: No

1 / 1

CAT#:0804-HY-101448RSize:1 Each

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

TMI-1 (Standard) is the analytical standard of TMI-1. This product is intended for research and analytical applications. TMI-1 (WAY-171318) inhibits TNF converting enzyme (TACE) (IC50 of 8.4 nM), ADAM-TS-4, ADAM-17 and various MMPs with oral activity. TMI-1 significantly suppresses the secretion of TNF-α , alleviating collagen-induced arthritis in mice. TMI-1 inhibits cancer cell proliferation, induces apoptosis through a caspase-dependent pathway. TMI-1 also reverses TRPV1 upregulation and lowers the levels of inflammatory factors (TNF-α、IL-1β、IL-6) in nerve cells, protecting against paclitaxel-induced neurotoxicity. TMI-1 leads to changes in pro-atherogenic lipoprotein profiles, but does not affect the progression of early lesions[1][2][3][4].

CAS Number

287403-39-8

Target

Apoptosis; Caspase; Interleukin Related; MMP; Reference Standards; TNF Receptor

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; Others

Field of Research

Cancer; Infection; Inflammation/Immunology; Neurological Disease

Smiles

O=C([C@@H]1N(S(=O)(C2=CC=C(OCC#CC)C=C2)=O)CCSC1(C)C)NO

Molecular Formula

C17H22N2O5S2

Molecular Weight

398.50

References & Citations

[1]Zhang Y, et al. Identification and characterization of 4-[[4- (2-butynyloxy) phenyl]sulfonyl]-N-hydroxy-2,2-dimethyl- (3S) thiomorpholinecarboxamide (TMI-1), a novel dual tumor necrosis factor-alpha-converting enzyme/matrix metalloprotease inhibitor for the treatment of rheumatoid arthritis. J Pharmacol Exp Ther. 2004 Apr;309 (1) :348-55.|[2]Mezil L, et al. Tumor selective cytotoxic action of a thiomorpholin hydroxamate inhibitor (TMI-1) in breast cancer. PLoS One. 2012;7 (9) :e43409.|[3]Yesul Kim, et al. TMI-1, TNF-α-Converting Enzyme Inhibitor, Protects Against Paclitaxel-Induced Neurotoxicity in the DRG Neuronal Cells In Vitro. Front Pharmacol. 2022 Feb 16:13:842779.|[4]Wynand Melenhorst, et al. ADAM17 INHIBITION IN APOE DEFICIENT MICE RESULTS IN A PROATHEROGENIC LIPOPROTEIN PROFILE WITHOUT AFFECTING ATHEROSCLEROSIS. University of Groningen.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Related Products

Catalog	Name
HY-101448-01	TMI-1
HY-34444R	1,1-Dioxothiolan (Standard)
HY-N2512R-01	1-Monomyristin (Standard)
HY-I1120R	SGLT2-IN-1 (Standard)
HY-Y1217R-01	1-Cyclohexanol (Standard)
HY-W017241R-01	1-Naphthalenemethanol (Standard)
HY-W004296R	1-Heptadecanol (Standard)
HY-15701R-01	Leukadherin-1 (Standard)
HY-13464R	ALK-IN-1 (Standard)
HY-121993R	Combretastatin A-1 (Standard)

Alternative Products

Catalog	Name
350336	Peptide Standard 1
TMB_MCFAR_1_1	McFarland Standard 1 1 Unit
OR1101406-01	1,1,1,2-Tetrachloroethane Standard
WINE-1	Organic Wine Standard 1
92654-1	Standard Nutrient Agar No.1
DM 2224	Standard Nutrient Broth No. 1
GTR18890999	Peptide Standard 1 peptide
BNT242	AURES - Standard 1 Set
92654-01	Standard Nutrient Agar No.1
C160-50UL	Endothelin-1 Standard, 50UL

TMI-1 (Standard)

Related Products

Alternative Products

Popular Products