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MPT0B392 (Standard)

CAT: 0804-HY-101287RSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-101287RSize:1 Each
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Description
MPT0B392 (Standard) is the analytical standard of MPT0B392. This product is intended for research and analytical applications. MPT0B392, an orally active quinoline derivative, induces c-Jun N-terminal kinase (JNK) activation, leading to apoptosis. MPT0B392 inhibits tubulin polymerization and triggers induction of the mitotic arrest, followed by mitochondrial membrane potential loss and caspases cleavage by activation of JNK and ultimately leads to apoptosis. MPT0B392 is demonstrated to be a novel microtubule-depolymerizing agent and enhances the cytotoxicity of sirolimus in sirolimus-resistant acute leukemic cells and the multidrug resistant cell line[1].
CAS Number
1346169-92-3
Target
Apoptosis; Caspase; JNK; Microtubule/Tubulin; Reference Standards
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; MAPK/ERK Pathway; Others
Field of Research
Cancer
Smiles
NC1=C2C(N=C(S(=O)(C3=CC(OC)=C(OC)C(OC)=C3)=O)C=C2)=CC=C1OC
Molecular Formula
C19H20N2O6S
Molecular Weight
404.44
References & Citations
[1]Chao MW, et al. An oral quinoline derivative, MPT0B392, causes leukemic cells mitotic arrest and overcomes drug resistant cancer cells. Oncotarget. 2017 Apr,8 (17) :27772-27785.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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