Luzindole (Standard)

CAT: 0804-HY-101254RSize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-101254RSize:1 Each
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Description
Luzindole (Standard) is the analytical standard of Luzindole. This product is intended for research and analytical applications. Luzindole (N-0774) is a selective melatonin receptor antagonist. Luzindole preferentially targets MT2 (Mel1b) over MT1 (Mel1a) with Ki values of 10.2 and 158 nM for human MT2 and MT1, respectively. Luzindole suppresses experimental autoimmune encephalomyelitis (EAE), and exerts antidepressant-like activity[1][2][3].
CAS Number
[117946-91-5]
Product Name Alternative
N-0774 (Standard)
UNSPSC
12352005
Target
Melatonin Receptor; Reference Standards
Related Pathways
GPCR/G Protein; Neuronal Signaling; Others
Field of Research
Neurological Disease
Smiles
CC(NCCC1=C(CC2=CC=CC=C2)NC3=C1C=CC=C3)=O
Molecular Formula
C19H20N2O
Molecular Weight
292.37
References & Citations
[1]Dubocovich ML, et al. Melatonin receptor antagonists that differentiate between the human Mel1a and Mel1b recombinant subtypes are used to assess the pharmacological profile of the rabbit retina ML1 presynaptic heteroreceptor. Naunyn Schmiedebergs Arch Pharmacol. 1997 Mar;355 (3) :365-75.|[2]Constantinescu CS, et al. Luzindole, a melatonin receptor antagonist, suppresses experimental autoimmune encephalomyelitis. Pathobiology. 1997;65 (4) :190-4.|[3]Dubocovich ML Antidepressant-like activity of the melatonin receptor antagonist, luzindole (N-0774), in the mouse behavioral despair test. Eur J Pharmacol. 1990 Jul 3;182 (2) :313-25.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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