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Dealanylascamycin

CAT: 0804-HY-101136Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-101136Size:1 Each
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Description
Dealanylascamycin (AT-265) (Compound 2) is a nucleoside antibiotic. AT 265 is a carbonic anhydrase (CA) inhibitor, with Ki values of 167, 65.2, 234, and 143 nM for hCA I, hCA II, hCA IV, and hCA IX respectively. Dealanylascamycin is the active form of Ascamycin. Dealanylascamycin exhibits broad-spectrum antibacterial activity and is effective against pathogenic bacteria such as Xanthomonas citri (MIC = 0.4 μg/mL). Dealanylascamycin has high cytotoxicity[1][2].
CAS Number
66522-52-9
Product Name Alternative
AT-265
UNSPSC
12352005
Hazard Statement
H315-H319-H335
Target
Antibiotic; Bacterial; Carbonic Anhydrase
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Field of Research
Infection
Smiles
O[C@H]1[C@@H](O)[C@H](N2C3=NC(Cl)=NC(N)=C3N=C2)O[C@@H]1COS(N)(=O)=O
Molecular Formula
C10H13ClN6O6S
Molecular Weight
380.76
Precautions
P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501
References & Citations
[1]Mujumdar P, et al. Synthesis, structure and bioactivity of primary sulfamate-containing natural products. Bioorg Med Chem Lett. 2018 Sep 15;28 (17) :3009-3013.|[2]Isono K, et al. Ascamycin and dealanylascamycin, nucleoside antibiotics from Streptomyces sp. J Antibiot (Tokyo) . 1984 Jun;37 (6) :670-2.
Shipping Conditions
Room temperature
Scientific Category
Reference compound2
Clinical Information
No Development Reported
Isoform
CA II; CA I; CA IX

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